Klasifikacija i kliniËki znaËaj kardiomiopatija Classification and clinical importance of cardiomyopathies
نویسنده
چکیده
I n this issue of Kardio list, Elliott and Mohiddin have published in the Almanac 2011 an excellent review article on the latest achievements and knowledge of diagnostics, pathogenesis and treatment, especially genomics and genetics of cardiomyopathies. I thought that the Editorial should address the existing definitions, classifications, general features and clinical significance of the most common types of the disease. Cardiomyopathies are the heart muscle diseases characterized by progression, often with a long and unidentified asymptomatic phase. They are one of the most complex, interesting and intriguing group of heart diseases. Apart from a few exceptions, histologically we distinguish between hypertrophy of cardiomyocytes, necrosis and/or fibrosis. Symptoms and signs of the disease in the majority of patients are the consequence of the development of dysfunction of the left or both ventricles, often accompanied by progression to manifest heart failure (HF) which is in the majority of patients a cause of death. My first patient, a young woman aged 19, with dilated cardiomyopathy was treated by me in 1981, when the disease was rarely diagnosed in general, and when mainly patients with acquired valvular or congenital heart defects prevailed among hospitalized patients. Over the past 30 years at the Department of Cardiology II, of the University Hospital Sestre milosrdnice there were over 3000 patients with primary and secondary cardiomyopathies hospitalized. Cardiomyopathies are not rare today, and also great progress has been made in understanding their pathogenesis and treatment options. Unfortunately, the disease is still often discovered in an advanced stage when the disease prognosis is bad.
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